Serrapeptase Information

Enzymes are catalysts, made from amino acids by RNA (Ribonucleic Acid) which is made by DNA (Deoxyribonucleic Acid). Enzymes need a specific temperature and pH (measure of acidity/alkalinity) to perform their work. Enzymes from plants work best at the human body’s temperature and pH. They are essential in every function of growth, repair and therefore health of every living cell in the body.

Thousands of enzymes are working every second to build and regenerate the body. They are constantly being converted or produced and they depend upon good living nutrition to keep ahead of daily damage and degeneration. They do need help in this job and this essential help comes from coenzymes. These are critical vitamins and minerals such as Vitamin B12. Even a small deficiency in B12 results in disease. This becomes such a problem with elderly people, on poor diets, that they at times need injections.

Another coenzyme, zinc, is needed by about 80 enzyme activities, not to mention the famous coenzyme Q10. Without enzymes and coenzymes, there would be no living thing. All living things depend upon enzymes to sustain growth and health.

Three Types Of Enzymes

Food/Digestive Enzymes – These take the basic building blocks delivered by food we eat and convert it to colloidal particles (the smallest particles that exist in a free state) that can be converted into healthy living tissue.

Metabolic Enzymes – Metabolic enzymes use these colloids to keep all of our organs and tissues functioning with hundreds of diverse chemical activities, repairing organs and fighting disease. The body’s ability to stay healthy, to repair tissue when injured, to protect us from disease, is directly related to the quality and number of enzymes, coenzymes and nutritious food.

Clean-Up Enzymes – This third type is not really a separate group, but they are the enzymes for the last job on the line, clearing up. They are responsible for eliminating the mess, left in the body from the construction and repair work that is in continuous operation. These clean-up enzymes clear our bodies of the undigested carbohydrates, proteins and any non-vital tissue floating around. Another vital job is to provide anti-inflammatory enzymes to fight infections and tissue damage.

Enzymes Do Specific Jobs, Including

♦ Digesting food
♦ Breaking down toxins
♦ Cleansing the blood
♦ Supporting the immune system
♦ Converting protein into muscle
♦ Contracting muscles
♦ Eliminating carbon dioxide from the lungs
♦ Supporting the pancreas and other vital organs

Enzymes are the workers in the body – they carry out every chemical reaction. To have a healthy body you need both workers (enzymes) and building materials. The building materials are proteins (amino acids), minerals, and vitamins. All of these are necessary to build a healthy body. Trying to function without all the necessary enzymes is the reason for most body malfunctions.

Seven Categories Of Food Enzymes

♦ Lipase to break down fat;
♦ Protease to breakdown protein
♦ Cellulase to break down fibres
♦ Amylase to break down starch
♦ Lactase to break down dairy foods
♦ Sucrase to breakdown sugars
♦ Maltase to breakdown grain

The Inflammatory Response

The inflammatory response is normally an important mechanism for protecting the body from attack by invading organisms, faulty cells and trauma. When the immune system becomes dysfunctional, it loses its ability to differentiate between innocuous and potentially dangerous substances. This dysfunction results in a wide array of autoimmune diseases such as rheumatoid arthritis, ulcerative colitis, allergies, psoriasis, uveitis, multiple sclerosis and some forms of cancer.

In spite of the huge range of successful enzyme studies showing safety and effectiveness, the standard therapy for inflammatory-mediated diseases and trauma include drugs such as steroids and non-steroidal anti-inflammatory agents (NSAIDs). These classes of drugs, in most cases, do offer temporary, symptomatic relief from swelling, inflammation and accompanying pain, but without treating the underlying condition.

Non-steroidal Anti-inflammatory Drugs (NSAIDs) And Their Side Effects

The drugs used to control the inflammatory response may be immunosuppressive and cause dangerous side effects. The benefits and long-term risks associated with the use of NSAIDs, especially in cases of rheumatoid arthritis; need to be weighed very carefully. If not successfully treated, the inflammatory process itself can lead to limitation of joint function and destruction of bone, cartilage and articular structures.

NSAIDs are one of the most widely prescribed drugs for rheumatoid arthritis and other inflammatory joint conditions. They inhibit the biosynthesis of prostaglandins by irreversibly blocking cyclooxygenase, the enzyme which catalyses the reactions of arachidonic acid to endoperoxide compounds.

The neurological and gastrointestinal side effects of these agents have been reviewed in considerable detail. All of the NSAIDs, with the exception of Cytotec, inhibit prostaglandin El, a local hormone responsible for gastric mucosal cytoprotection. A common side effect from these medications is gastric ulcers. Adverse reactions that are more serious such as blood dyscrasias, kidney damage and cardiovascular effects have been noted. Most physicians rotate among the ten most widely prescribed NSAIDs, as soon as one causes side effects or stops working.

Introducing Serrapeptase, The ‘Miracle’ Enzyme

The search for a superior enzyme that offers safe but powerful anti-inflammatory properties, thus averting the terrible side effects, ended when Serratia peptidase (Serrapeptase) enzyme was discovered in the early 1970′s. Serrapeptase is now in wide clinical use throughout Europe and Asia as a viable alternative to salicylates, ibuprofen (sold as an OTC in the USA.) and the more potent NSAIDs. Serrapeptase is an anti-inflammatory, proteolytic enzyme isolated from the micro-organism, Serratia E15 and has no inhibitory effects on prostaglandins, is devoid of gastrointestinal side effects and offers a sensible alternative.

Serrapeptase is processed commercially in the laboratory through fermentation. It was originally found in the silkworm where it is naturally present in its intestine. This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. Histologic studies reveal powerful anti-inflammatory effects of this naturally occurring enzyme. The silkworm has a special relationship with the Serratia E15 micro-organisms in its intestines. The enzymes secreted by the bacteria in silkworm intestines have the ability to dissolve avital tissue, but have no detrimental effect on the host’s living cells. Thus by dissolving the silkworm’s protective cocoon (avital tissue), the winged creature is able to emerge and fly away.

The mechanisms of action of Serrapeptase, at the sites of various inflammatory processes consist fundamentally of a reduction of the exudative phenomena and an inhibition of the release of the inflammatory mediators. This peptidase induces fragmentation of fibrinous aggregates and reduces the viscosity of exudates, thus facilitating drainage of these products of the inflammatory response and thereby promoting the tissue repair process. Studies suggest that Serrapeptase has a modulatory effect on specific acute phase proteins that are involved in the inflammatory process. This is substantiated by a report of significant reductions in C3 and C4 complement, increases in opsonising protein and reductions in concentrations of haptoglobulin, which is a scavenger protein that inhibits lysosomal protease.

Enteric Coating For Intestinal Absorption

Several research groups have reported the intestinal absorption of Serrapeptase. Serrapeptase is well absorbed orally when formulated with an enteric coating. It is known that proteases and peptidases are only absorbed in the intestinal area.

These enzymes are mobilised directly to the blood and are not easily detectable in urine. Other enzymes with structural similarities have been reported to be absorbed through the intestinal tract. Chymotrypsin is transported into the blood from the intestinal lumen. Horseradish peroxidase can cross the mucosal barrier of the intestine in a biologically and immunologically active form. Several studies have appeared so far which refer to the systemic effects of orally given proteases and peptidases (e.g. Serrapeptase), such as repression of oedema and repression of blood vessel permeability induced by histamine or bradykinin. These enzymes also affect the kallikrein-kinin system and the complement system, thus modifying the inflammatory response.

Superior Effects

In vitro and in vivo studies reveal that Serrapeptase has a specific, anti-inflammatory effect, superior to that of other proteolytic enzymes. A review of the scientific literature, including a series of controlled, clinical trials with large patient groups, suggests that Serrapeptase is useful for a broad range of inflammatory conditions. If one considers the fact that anti-inflammatory agents are among the most widely prescribed drugs, the use of a safe, proteolytic enzyme such as Serrapeptase would be a welcome addition to the physician’s armamentarium of physiologic agents

Serrapeptase Has A Wide Range of Applications

The discovery of this unique biological phenomenon led researchers to study clinical applications of the Serrapeptase enzyme in man.

Researchers in Germany have used Serrapeptase for atherosclerosis to digest atherosclerotic plaque without harming the healthy cells lining the arterial wall. Today, researchers consider atherosclerosis an inflammatory condition (similar to many other degenerative diseases whose cause is identified as chronic inflammation). Some immunologists are even categorising atherosclerosis as a benign tumour. Hardening and narrowing of the arterial wall is a cumulative result of microscopic trauma; inflammation occurs in the presence of oxidised lipids. Serrapeptase does not interfere with the synthesis of cholesterol in the body, but acts as an anti-inflammatory and helps clear avital tissue from the arterial wall. It is important to note that cholesterol in its pure state is an antioxidant and a necessary component of the major organ and hormonal systems in the body. The use of medications, which block cholesterol biosynthesis, may eventually damage the liver and compromise antioxidant status of the eyes, lungs and other soft tissues.

Powerful Anti-inflammatory

In addition to atherosclerosis, there is a growing list of conditions, which respond to Serrapeptase simply taken orally in tablet or capsule form.

Pain Of Any Kind

♦ Arthritis
♦ Multiple Sclerosis
♦ Rheumatoid Arthritis
♦ Headaches and Migraines (Caused by Inflammation)

Lung Problems

♦ Emphysema
♦ Bronchitis
♦ Pulmonary Tuberculosis
♦ Bronchial Asthma
♦ Bronchiectasis

Eye Problems

♦ Inflammation
♦ Blocked Veins etc

ENT Problems

♦ Sinusitis
♦ Chronic Ear Infections
♦ Runny Nose etc

Trauma

♦ Sports Injuries
♦ Traumatic Swelling
♦ Post Operative
♦ Leg Ulcers (that are not healing)

Inflammation Of Any Kind

♦ Inflammatory Bowel (Crohn’s, colitis etc)
♦ Cystitis
♦ Fibromyalgia
♦ Breast Engorgement
♦ Fibrocystic Breast
♦ Varicose Veins etc

Cardiovascular

♦ Varicose Veins etc
♦ Cardiovascular Disease

* Please note: This list is not definitive and it does not constitute advice of any kind.
** Where appropriate standard British English spelling has been used.

With thanks to Robert Redfern of Naturally Healthy Publications, for original information.

Article Edited By Mike Tawse

Research References

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More Information

The ‘Miracle’ Enzyme is Serrapeptase – The 2nd Gift from Silkworms (by Robert Redfern) A remarkable book about a remarkable enzyme. Read in detail, the fascinating studies, uses and practitioner’s reports about Serrapeptase.

Serrapeptase Information Website.

Serrapeptase News (Robert Redfern’s Serrapeptase Newsletters).

I informed you some years ago that Serrapeptase is apparently active in the cleaning of coronary arteries from occluding layers. The results are so spectacular that even Tom Valentine reported on this progress in the US (DC) press after speaking to several parties here.

Serrapeptase is an enzyme produced by serratia bacteria living on silkworms. With this enzyme the worms melt a hole out of the cocoon. Unlike other enzymes in the field of biology, Serrapeptase dissolves ‘dead’ tissue like or e.g. not both silk and apparently also fibrinoid layers in the arteries which chemically could be compared to silk.

A special problem in today’s civilized society is occluding processes in the carotid arteries of the neck. Very often we see patients where surgeons were reluctant to operate or to apply drill or laser technology such occluded carotids. The reason for this is the potential risk that off coming debris will be pushed into the smaller cerebral vessels.

We have, therefore started to apply Serrapeptase in cases of severe narrowings of the carotid arteries. Mostly in patients showing severe symptoms due to the narrowing, including amaurosis fugax (intermittent blindness). The therapeutic results are excellent, certainly lifesaving. It is, however, mandatory that the therapy be conducted for a very long time. The first reliable results can be expected after 6-8 months. Even after month 18, after the onset of the therapy, the patients are improving.

I have also found Serrapeptase to be an extraordinary substance for safety removing fibrous blockages from coronary arteries, particularly the carotid arteries found in the neck, which supply blood brain. Serrapeptase is a natural enzyme produced by serratia bacteria living in silkworms. Once the silkworm has completed its transformation into a moth, it uses this substance to “melt” a hole in its cocoon, so that it can escape.

The astonishing fact is that, unlike other biological enzymes, Serrapeptase affects only non-living tissue, like the silk cocoon. This is the reason the butterfly is not harmed. For our health purposes, Serrapeptase dissolves only dead tissues such as the old fibrous layers that clog the lining of our arteries and dangerously restrict the flow of blood and oxygen to the brain. Because of this, Serrapeptase is extremely useful in keeping arterial deposits from building up again after angioplasty (a balloon technique used to clear an artery blockage) or coronary bypass surgery has been performed.

Very often, surgeons are reluctant or unable to open partially closed carotid arteries using laser surgery. They fear that resulting debris could be pushed into smaller connecting arteries and result in a stroke and possibly death. In cases of severe arterial narrowing, I have used Serrapeptase with excellent, even life-saving results. Many of my patients have shown significant improved blood flow through their previously constricted arteries, as confirmed by ultrasound examination. Unfortunately, orthodox cardiologists do not employ this important method in their practices.

Dr H. A. Nieper
Head, Dept of Medicine
Paracelcus Klink am Silbersee Oertzeweg 24
38051 Langenhagen, Germany
0511-7782-54
Fax: 0511 7782 54

Article by: Dr. H A Nieper

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‘Serrapeptase Gave Me Back My Life!’

‘Ripples on water, the myriad shapes of leaves and plants: because of my poor eyesight I never expected to see these beauties. They were limited to my imagination based on friends’ descriptions. Now everything has changed, I am seeing the world with fresh eyes.’ This poetic description of Mike Tawse’s regained sight marks the latest chapter in his Serrapeptase Adventure.

The inspiring story of one man’s victory over his life-threatening health condition even persuaded Robert Redfern to rename his book The Miracle Enzyme is Serrapeptase. Says Robert: ‘I was finally convinced to change the name of the book and to create an accompanying web site www.themiracleenzyme.info when the story of Mike Tawse first surfaced.’

It begins in December 2005, The scene: a ground floor flat near Manchester University, The 36 year old sits in his wheelchair – as he has for the previous ten years – and wonders if he will have (or wants) another year of life. Born with cerebral palsy he is now hardly able to speak, the fluid from his lungs nearly choking him, his heart and lungs failing. His concerned friends are so anxious they have discussed what arrangements he wants for his funeral.

The turning point came on January 3, 2006 when Mike was persuaded to start taking 2 SerraEzyme tablets twice a day. A friend had heard how an enzyme called Serrapeptase was achieving a reputation for its power as an anti-inflammatory, pain reliever and for clearing inflamed tissue in the body. What followed is an incredible journey, spanning two years, that has taken Mike from a purgatory of illness to the joy of health.

He started a blog, (www.serrapeptaseadventure.ws) which became an ongoing message of inspiration. As he says: ‘The reason for putting my story out there was not so much for myself but worth it if just one person read it and was persuaded to try this route.’

Results came thick and fast. 24 Feb 2006 Mike wrote: ‘for the last seven days, my lung function has been great. It has been no lower than 500 litres per minute, and usually around 530 litres. It seems to me that it may well be settling. My heart rate remains normal, and even the condition of my skin seems improved. I have now completely stopped all my prescription medication and continue to feel stronger, eating and sleeping better.’

May 25, 2006. This is a celebratory blog as Mike describes his ‘first twenty steps’. ‘For several weeks, I have been experimenting with standing, with crutches, but not had the confidence to walk. After recovering from a stomach bug, I got back on my feet thinking I would stand for a few minutes, and that would be that. After about five minutes, my phone rang. Without conscious thought, I found I had taken the 20 steps to answer it. It was yet another sign I was regaining control over my condition instead of it having control over me.’

Life, which had seemed to be diminishing, now opened up. Mike was invited onto the Power Hour, an American talk show hosted by Joyce Riley. She had previously interviewed Robert Redfern about help for cerebral palsy. He described Mike’s experience.

Says Mike: ‘Joyce has a strong spiritual faith. One of the questions she asked me was ‘Do you believe in miracles?’ I replied, ‘If I didn’t in the past I do now.’

Five months later, he wrote: ‘After careful, detailed checks of my heart function, blood pressure and lung function, all confirmed as normal, it has been agreed that I am very unlikely to need prescribed medication ever again.’

As Mike points out, there is a lot of confusion surrounding cerebral palsy. There are people who believe it is an illness that can be cured, whereas it is a condition that, as he has proved, can be ameliorated. However, the dramatic improvement in his eyesight and visual perception remains a mystery factor. This second year of Mike’s Serrapeptase Adventure has undoubtedly been dominated by this event. He feels it is the most exciting and unexpected of all.

‘It is obvious to me that the problems with my heart, lung function and digestive system were most likely caused or exacerbated by the medication I was given to manage symptoms. Serrapeptase gave me a way of managing my condition without them and the chance to recover from their effects.

My development of depth perception is very different. The reason why I have never experienced it before is a direct result of the underlying brain damage. To the best of my knowledge, it is not possible to recover a skill never previously available. The dramatic improvement in my vision remains the mystery factor.

Robert Redfern described Serrapeptase as ‘the miracle enzyme’; it is a description I believe is well deserved.’

Mike Tawse: Serrapeptase Gave Me Back My Life… The progress continues today, in 2009. Please visit my website, to read the full story.

www.serrapeptaseadventure.ws

Article by: Jenny Pulling

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